Kefc C-terminal domain in complex with keff and esg

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 17% strand (DSSP).

Ligands and binding sites

• FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
• ESG · L-gamma-glutamyl-S-[(3S)-1-ethyl-2,5-dioxopyrrolidin-3-yl]-L-cysteinylglycine · ligand · chains A, B
• L9X · L-gamma-glutamyl-S-[(3R)-1-ethyl-2,5-dioxopyrrolidin-3-yl]-L-cysteinylglycine · ligand · chains A, B
• ZN · Zinc ion · metal · 2 copies · chains A, B
• SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 4406 Ų buried · 53 hydrogen bonds · protein-protein

Compared structures

• 3L9X · KefC C-terminal domain in complex with KefF and ESG · the same entry in another collection · chain B against B, TM-score 1.00
• P0A754 · AlphaFold monomer V2.0 prediction for glutathione-regulated potassium-efflux system… · a predicted model of the same protein · chain A against A, TM-score 0.52
• P03819 · AlphaFold monomer V2.0 prediction for glutathione-regulated potassium-efflux system… · a predicted model of the same protein · chain A against A, TM-score 0.48

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P03819
• Every structure of UniProt P0A754
• Elsewhere: RCSB PDB 3L9X · PDBe 3L9X · UniProt P03819 · UniProt P0A754