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Crystal structure of a domain of brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldina-inhibited gep 2) from homo sapiens (human). northeast structural genomics consortium target id HR5562A

Analyse Crystal structure of a domain of brefeldin a-inhibited guanine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3L8N
Type: protein
Length: 179 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Brefeldin a-inhibited guanine nucleotide-exchange protein 2
UniProt: Q9Y6D5
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Brefeldin a-inhibited guanine nucleotide-exchange protein 2	protein	179	44% helix, 1% strand	Q9Y6D5

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	81	0.37	0.76	14	empty

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

3L8N · Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange… · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y6D5 · AlphaFold monomer V2.0 prediction for brefeldin a-inhibited guanine nucleotide-exchange… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y6D5
Elsewhere: RCSB PDB 3L8N · PDBe 3L8N · UniProt Q9Y6D5

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