Research workbench
Crystal structure of mete from streptococcus mutans
Analyse Crystal structure of mete from streptococcus mutans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3L7R
- Type
- protein
- Length
- 736 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- EC
- 2.1.1.14
- UniProt
- Q8CWX6
- Ligands
- ZN, SO4
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) | protein | 736 | 46% helix, 15% strand | Q8CWX6 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.77 | 0.79 | 106 | ZN |
| 2 | 74 | 0.73 | 0.97 | 21 | empty |
| 3 | 152 | 0.63 | 0.85 | 30 | empty |
| 4 | 164 | 0.61 | 0.84 | 26 | empty |
| 5 | 250 | 0.60 | 0.79 | 20 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3L7R · crystal structure of MetE from streptococcus mutans · the same entry in another collection · chain A against A, TM-score 1.00
- Q8CWX6 · AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8CWX6
- Elsewhere: RCSB PDB 3L7R · PDBe 3L7R · UniProt Q8CWX6
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