Research workbench
Crystal structure of the mouse condensin hinge domain
Analyse Crystal structure of the mouse condensin hinge domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3L51
- Type
- protein
- Length
- 321 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein 2; Structural maintenance of chromosomes…
- UniProt
- Q8CG48, Q8CG47
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein 2 | protein | 155 | 43% helix, 17% strand | Q8CG48 |
| B | Structural maintenance of chromosomes protein 4 | protein | 166 | 46% helix, 16% strand | Q8CG47 |
Ligands and binding sites
- GOL · Glycerol · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.34 | 0.72 | 19 | GOL |
| 2 | 74 | 0.28 | 0.72 | 15 | GOL |
Interfaces
1 interface between chains.
- A–B · 754 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 3L51 · Crystal Structure of the Mouse Condensin Hinge Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q8CG48 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q8CG47 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 4… · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8CG48
- Every structure of UniProt Q8CG47
- Elsewhere: RCSB PDB 3L51 · PDBe 3L51 · UniProt Q8CG48 · UniProt Q8CG47
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