Research workbench
PIE12 D-peptide against HIV entry
Analyse PIE12 D-peptide against HIV entry in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3L37
- Type
- protein
- Length
- 61 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GP41 N-peptide; HIV entry inhibitor PIE12
- Ligands
- ACE, NH2
Structure
x-ray diffraction · 2 distinct chains · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GP41 N-peptide | protein | 45 | 96% helix, 0% strand | — |
| H | HIV entry inhibitor PIE12 | protein | 16 | 63% helix, 0% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · 2 copies · chains A, H
- NH2 · Amino group · ion · 2 copies · chains A, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–H · 389 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 d-amino, 2 covalent, 1 disulfide (D-amino acid, covalent ligand, disulfide).
Compared structures
- 3L37 · PIE12 D-peptide against HIV entry · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3L37 · PDBe 3L37
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.