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Crystal structure of zaire ebola VP35 interferon inhibitory domain K319A/R322A mutant

Analyse Crystal structure of zaire ebola VP35 interferon inhibitory domain K319A/R322A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3L29
Type: protein
Length: 250 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase cofactor VP35
UniProt: Q05127
Ligands: CL
Pockets: 1 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase cofactor VP35	protein	123	54% helix, 15% strand	Q05127
B	Polymerase cofactor VP35	protein	127	51% helix, 13% strand	Q05127

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	778	0.70	0.76	56	empty

Interfaces

1 interface between chains.

A–B · 249 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3L29 · Crystal Structure of Zaire Ebola VP35 interferon inhibitory domain K319A/R322A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05127
Elsewhere: RCSB PDB 3L29 · PDBe 3L29 · UniProt Q05127

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