Research workbench
Structure of split monoubiquitinated PCNA with ubiquitin in position one
Analyse Structure of split monoubiquitinated PCNA with ubiquitin in position one in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3L10
- Type
- protein
- Length
- 329 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proliferating cell nuclear antigen; Monoubiquitinated proliferating cell nuclear antigen
- UniProt
- P15873, P61864
- Pockets
- 4 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proliferating cell nuclear antigen | protein | 163 | 21% helix, 40% strand | P15873 |
| B | Monoubiquitinated proliferating cell nuclear antigen | protein | 166 | 19% helix, 42% strand | P15873, P61864 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.49 | 0.77 | 21 | empty |
| 2 | 138 | 0.42 | 0.75 | 20 | empty |
| 3 | 88 | 0.39 | 0.77 | 17 | empty |
| 4 | 67 | 0.36 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 3007 Ų buried · 66 hydrogen bonds · protein-protein
Compared structures
- 3L10 · Structure of split monoubiquitinated PCNA with ubiquitin in position one · the same entry in another collection · chain A against A, TM-score 1.00
- P15873 · AlphaFold monomer V2.0 prediction for proliferating cell nuclear antigen (P15873) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15873
- Every structure of UniProt P61864
- Elsewhere: RCSB PDB 3L10 · PDBe 3L10 · UniProt P15873 · UniProt P61864
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