Research workbench
Saccharomyces cerevisiae CET1-CEG1 capping apparatus
Analyse Saccharomyces cerevisiae CET1-CEG1 capping apparatus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3KYH
- Type
- protein
- Length
- 1,326 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA-capping enzyme subunit beta; MRNA-capping enzyme subunit alpha
- EC
- 3.1.3.33, 2.7.7.50
- UniProt
- O13297, Q01159
- Pockets
- 15 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | MRNA-capping enzyme subunit beta (EC 3.1.3.33) | protein | 276 | 27% helix, 29% strand | O13297 |
| C, D | MRNA-capping enzyme subunit alpha (EC 2.7.7.50) | protein | 387 | 28% helix, 27% strand | Q01159 |
Pockets
15 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 875 | 0.77 | 0.80 | 73 | empty |
| 2 | 1115 | 0.74 | 0.77 | 89 | empty |
| 3 | 169 | 0.73 | 0.91 | 32 | empty |
| 4 | 310 | 0.72 | 0.85 | 44 | empty |
| 5 | 172 | 0.69 | 0.87 | 29 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2610 Ų buried · 35 hydrogen bonds · protein-protein
- A–D · 1064 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1038 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 397 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 374 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3KYH · Saccharomyces cerevisiae Cet1-Ceg1 capping apparatus · the same entry in another collection · chain C against C, TM-score 1.00
- O13297 · AlphaFold monomer V2.0 prediction for mRNA-capping enzyme subunit beta (O13297) · a predicted model of the same protein · chain A against A, TM-score 0.92
- Q01159 · AlphaFold monomer V2.0 prediction for mRNA-capping enzyme subunit alpha (Q01159) · a predicted model of the same protein · chain C against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13297
- Every structure of UniProt Q01159
- Elsewhere: RCSB PDB 3KYH · PDBe 3KYH · UniProt O13297 · UniProt Q01159
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