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Crystal structure of ssgbp mutation variant G235P

Analyse Crystal structure of ssgbp mutation variant G235P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3KXK
Type: protein
Length: 579 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTP-binding protein (hflx)
UniProt: Q980M3
Pockets: 6 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GTP-binding protein (hflx)	protein	293	47% helix, 22% strand	Q980M3
B	GTP-binding protein (hflx)	protein	286	47% helix, 21% strand	Q980M3

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.57	0.79	45	empty
2	135	0.49	0.79	32	empty
3	116	0.47	0.79	26	empty
4	61	0.41	0.81	17	empty
5	115	0.39	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 627 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3KXK · Crystal structure of SsGBP mutation variant G235P · the same entry in another collection · chain A against A, TM-score 1.00
Q980M3 · AlphaFold monomer V2.0 prediction for GTPase hflx (Q980M3) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q980M3
Elsewhere: RCSB PDB 3KXK · PDBe 3KXK · UniProt Q980M3

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