Research workbench

Refined crystal structure of beta-lactamase from citrobacter freundii indicates a mechanism for beta-lactam hydrolysis

Analyse Refined crystal structure of beta-lactamase from citrobacter freundii indicates… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1FR1
Type: protein
Length: 722 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
EC: 3.5.2.6
UniProt: Q46041
Pockets: 5 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-lactamase (EC 3.5.2.6)	protein	361	40% helix, 24% strand	Q46041

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	867	0.87	0.90	104	empty
2	387	0.77	0.87	53	empty
3	106	0.38	0.75	20	empty
4	53	0.36	0.80	15	empty
5	60	0.31	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 1476 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

1FR1 · Refined crystal structure of beta-lactamase from citrobacter freundii indicates a… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q46041
Elsewhere: RCSB PDB 1FR1 · PDBe 1FR1 · UniProt Q46041

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.