Research workbench
Structure of the central interaction protein from the trypanosoma brucei editosome in complex with single domain antibodies
Analyse Structure of the central interaction protein from the trypanosoma brucei… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3K81
- Type
- protein
- Length
- 449 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MP18 RNA editing complex protein; Single strand antibody vhh domain
- UniProt
- Q38B90
- Pockets
- 2 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 5% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | MP18 RNA editing complex protein | protein | 105 | 10% helix, 44% strand | Q38B90 |
| D | MP18 RNA editing complex protein | protein | 106 | 9% helix, 51% strand | Q38B90 |
| A | Single strand antibody vhh domain | protein | 118 | 3% helix, 42% strand | — |
| B | Single strand antibody vhh domain | protein | 120 | 0% helix, 33% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1173 | 0.80 | 0.81 | 136 | empty |
| 2 | 146 | 0.49 | 0.78 | 20 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1213 Ų buried · 18 hydrogen bonds · protein-protein
- D–A · 707 Ų buried · 7 hydrogen bonds · protein-protein
- C–B · 646 Ų buried · 9 hydrogen bonds · protein-protein
- C–A · 108 Ų buried · 2 hydrogen bonds · protein-protein
- D–B · 99 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3K81 · Structure of the central interaction protein from the Trypanosoma brucei editosome in… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q38B90
- Elsewhere: RCSB PDB 3K81 · PDBe 3K81 · UniProt Q38B90
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