Research workbench
Structure of essential protein from trypanosoma brucei
Analyse Structure of essential protein from trypanosoma brucei in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3K80
- Type
- protein
- Length
- 452 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody; MP18 RNA editing complex protein
- UniProt
- Q38B90
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 4 distinct chains · 10% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody | protein | 124 | 12% helix, 50% strand | — |
| B | Antibody | protein | 124 | 10% helix, 48% strand | — |
| D | MP18 RNA editing complex protein | protein | 101 | 10% helix, 63% strand | Q38B90 |
| C | MP18 RNA editing complex protein | protein | 103 | 10% helix, 58% strand | Q38B90 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.34 | 0.76 | 23 | empty |
| 2 | 63 | 0.28 | 0.73 | 18 | empty |
Interfaces
3 interfaces between chains.
- D–C · 1051 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 762 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 710 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3K80 · Structure of essential protein from Trypanosoma brucei · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q38B90
- Elsewhere: RCSB PDB 3K80 · PDBe 3K80 · UniProt Q38B90
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