Research workbench
Structure of mutant of ribose 5-phosphate isomerase type B from trypanosoma cruzi.
Analyse Structure of mutant of ribose 5-phosphate isomerase type B from trypanosoma… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3K7P
- Type
- protein
- Length
- 305 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribose 5-phosphate isomerase
- EC
- 5.3.1.6
- UniProt
- A1BTJ7
- Ligands
- PO4
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribose 5-phosphate isomerase (EC 5.3.1.6) | protein | 153 | 48% helix, 17% strand | A1BTJ7 |
| B | Ribose 5-phosphate isomerase (EC 5.3.1.6) | protein | 152 | 49% helix, 17% strand | A1BTJ7 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.62 | 0.90 | 22 | PO4 |
| 2 | 105 | 0.52 | 0.82 | 21 | PO4 |
| 3 | 50 | 0.51 | 0.88 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1873 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 3K7P · Structure of mutant of ribose 5-phosphate isomerase type B from Trypanosoma cruzi. · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A1BTJ7
- Elsewhere: RCSB PDB 3K7P · PDBe 3K7P · UniProt A1BTJ7
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