Research workbench
X-ray crystal structure of XRCC1
Analyse X-ray crystal structure of XRCC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3K77
- Type
- protein
- Length
- 1,216 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein XRCC1
- UniProt
- P18887
- Pockets
- 15 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 14% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | DNA repair protein XRCC1 | protein | 152 | 14% helix, 45% strand | P18887 |
Pockets
15 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 906 | 0.88 | 0.90 | 99 | empty |
| 2 | 475 | 0.76 | 0.84 | 53 | empty |
| 3 | 426 | 0.73 | 0.83 | 44 | empty |
| 4 | 293 | 0.64 | 0.80 | 40 | empty |
| 5 | 103 | 0.62 | 0.88 | 26 | empty |
Interfaces
14 interfaces between chains.
- C–H · 678 Ų buried · 1 hydrogen bond · protein-protein
- D–E · 643 Ų buried · 12 hydrogen bonds · protein-protein
- E–F · 520 Ų buried · 2 hydrogen bonds · protein-protein
- B–G · 436 Ų buried · 0 hydrogen bonds · protein-protein
- C–E · 366 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18887
- Elsewhere: RCSB PDB 3K77 · PDBe 3K77 · UniProt P18887
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