Research workbench
Estrogen related receptor alpha in complex with an ether based ligand
Analyse Estrogen related receptor alpha in complex with an ether based ligand in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3K6P
- Type
- protein
- Length
- 226 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Steroid hormone receptor ERR1
- UniProt
- P11474
- Ligands
- 5FB
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 67% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Steroid hormone receptor ERR1 | protein | 226 | 67% helix, 3% strand | P11474 |
Ligands and binding sites
- 5FB · 4-(4-{[(5R)-2,4-dioxo-1,3-thiazolidin-5-yl]methyl}-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 137 | 0.68 | 0.88 | 26 | 5FB |
| 2 | 85 | 0.54 | 0.85 | 22 | empty |
Compared structures
- 3K6P · Estrogen Related Receptor alpha in Complex with an Ether Based Ligand · the same entry in another collection · chain A against A, TM-score 1.00
- P11474 · AlphaFold monomer V2.0 prediction for steroid hormone receptor ERR1 (P11474) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11474
- Elsewhere: RCSB PDB 3K6P · PDBe 3K6P · UniProt P11474
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