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The crystal structure of sigma-54-dependent transcriptional regulator domain from chlorobium tepidum tls

Analyse The crystal structure of sigma-54-dependent transcriptional regulator domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3K2N
Type: protein
Length: 354 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sigma-54-dependent transcriptional regulator
UniProt: Q8KG60
Pockets: 8 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sigma-54-dependent transcriptional regulator	protein	177	38% helix, 24% strand	Q8KG60

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.80	0.91	33	empty
2	300	0.79	0.90	34	empty
3	78	0.54	0.86	17	empty
4	71	0.47	0.83	20	empty
5	79	0.46	0.82	20	empty

Interfaces

1 interface between chains.

A–B · 1294 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

3K2N · The crystal structure of sigma-54-dependent transcriptional regulator domain from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8KG60
Elsewhere: RCSB PDB 3K2N · PDBe 3K2N · UniProt Q8KG60

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