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Crystal structure of putative gamma-glutamylcysteine synthetase (YP_546622.1) from methylobacillus flagellatus kt at 1.90 a resolution
Analyse Crystal structure of putative gamma-glutamylcysteine synthetase (YP_546622.1)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3K1T
- Type
- protein
- Length
- 424 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate--cysteine ligase gsha
- UniProt
- Q1GYA6
- Ligands
- SO4, CL
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate--cysteine ligase gsha | protein | 424 | 36% helix, 25% strand | Q1GYA6 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · 9 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 793 | 0.75 | 0.79 | 70 | SO4, GOL |
| 2 | 122 | 0.51 | 0.81 | 30 | GOL |
| 3 | 94 | 0.42 | 0.78 | 20 | empty |
| 4 | 61 | 0.34 | 0.77 | 15 | empty |
| 5 | 50 | 0.32 | 0.78 | 14 | empty |
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 3K1T · Crystal structure of Putative gamma-glutamylcysteine synthetase (YP_546622.1) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1GYA6
- Elsewhere: RCSB PDB 3K1T · PDBe 3K1T · UniProt Q1GYA6
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