Research workbench
Human MDM2 liganded with a 12MER peptide inhibitor (PDI6W)
Analyse Human MDM2 liganded with a 12MER peptide inhibitor (PDI6W) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3JZR
- Type
- protein
- Length
- 109 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase MDM2; PDI6W peptide (12MER)
- EC
- 6.3.2.-
- UniProt
- Q00987
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase MDM2 (EC 6.3.2.-) | protein | 97 | 44% helix, 19% strand | Q00987 |
| P | PDI6W peptide (12MER) | protein | 12 | 50% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–P · 707 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3JZR · Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00987
- Elsewhere: RCSB PDB 3JZR · PDBe 3JZR · UniProt Q00987
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