Crystal structures of the gach receptor of streptomyces glaucescens GLA.O in the unliganded form and in complex with acarbose and an acarbose homolog. comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 21% strand (DSSP).

Ligands and binding sites

• AC1 · 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose · ligand · chains A
• GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3JYR · Crystal structures of the GacH receptor of Streptomyces glaucescens GLA.O in the… · the same entry in another collection · chain A against A, TM-score 1.00
• P19576 · AlphaFold monomer V2.0 prediction for MALTOSE/MALTODEXTRIN-binding periplasmic protein… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19576
• Elsewhere: RCSB PDB 3JYR · PDBe 3JYR · UniProt P19576