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Crystal structure of the chicken TRPV4 ankyrin repeat domain

Analyse Crystal structure of the chicken TRPV4 ankyrin repeat domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3JXJ
Type: protein
Length: 506 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vanilloid receptor-related osmotically activated channel protein
UniProt: Q9DFS3
Ligands: PO4
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Vanilloid receptor-related osmotically activated channel protein	protein	257	51% helix, 2% strand	Q9DFS3
B	Vanilloid receptor-related osmotically activated channel protein	protein	249	53% helix, 3% strand	Q9DFS3

Ligands and binding sites

PO4 · Phosphate ion · ion · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.43	0.78	17	empty
2	105	0.41	0.76	14	empty
3	61	0.26	0.72	16	empty

Compared structures

3JXJ · Crystal structure of the chicken TRPV4 ankyrin repeat domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9DFS3
Elsewhere: RCSB PDB 3JXJ · PDBe 3JXJ · UniProt Q9DFS3

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