Research workbench
Crystal structure of the chicken TRPV4 ankyrin repeat domain
Analyse Crystal structure of the chicken TRPV4 ankyrin repeat domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3JXI
- Type
- protein
- Length
- 1,007 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vanilloid receptor-related osmotically activated channel protein
- UniProt
- Q9DFS3
- Pockets
- 8 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 53% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vanilloid receptor-related osmotically activated channel protein | protein | 253 | 53% helix, 3% strand | Q9DFS3 |
| B | Vanilloid receptor-related osmotically activated channel protein | protein | 256 | 53% helix, 3% strand | Q9DFS3 |
| C, D | Vanilloid receptor-related osmotically activated channel protein | protein | 249 | 53% helix, 3% strand | Q9DFS3 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.57 | 0.78 | 33 | empty |
| 2 | 126 | 0.48 | 0.78 | 19 | empty |
| 3 | 155 | 0.47 | 0.77 | 19 | empty |
| 4 | 133 | 0.43 | 0.76 | 18 | empty |
| 5 | 93 | 0.43 | 0.78 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 496 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 412 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 86 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3JXI · Crystal structure of the chicken TRPV4 ankyrin repeat domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9DFS3
- Elsewhere: RCSB PDB 3JXI · PDBe 3JXI · UniProt Q9DFS3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.