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Structure of SH3E-dh unit of murine intersectin-1L

Analyse Structure of SH3E-dh unit of murine intersectin-1L in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3JV3
Type: protein
Length: 502 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Intersectin-1
UniProt: Q9Z0R4
Pockets: 4 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Intersectin-1	protein	278	64% helix, 10% strand	Q9Z0R4
B	Intersectin-1	protein	224	77% helix, 0% strand	Q9Z0R4

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1078	0.86	0.86	108	empty
2	239	0.58	0.79	34	empty
3	116	0.52	0.82	16	empty
4	81	0.49	0.83	20	empty

Interfaces

1 interface between chains.

A–B · 2040 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

3JV3 · Structure of SH3E-DH unit of murine intersectin-1L · the same entry in another collection · chain A against A, TM-score 1.00
Q9Z0R4 · AlphaFold monomer V2.0 prediction for intersectin-1 (Q9Z0R4) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Z0R4
Elsewhere: RCSB PDB 3JV3 · PDBe 3JV3 · UniProt Q9Z0R4

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