Research workbench
The crystal structure of apo- udp-glucose pyrophosphorylase
Analyse The crystal structure of apo- udp-glucose pyrophosphorylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3JUJ
- Type
- protein
- Length
- 1,092 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-glucose pyrophosphorylase (galu)
- EC
- 2.7.7.9
- UniProt
- O25363
- Pockets
- 16 · best druggability 0.90
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Udp-glucose pyrophosphorylase (galu) (EC 2.7.7.9) | protein | 273 | 37% helix, 25% strand | O25363 |
Pockets
16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1109 | 0.90 | 0.92 | 108 | empty |
| 2 | 587 | 0.73 | 0.81 | 51 | empty |
| 3 | 643 | 0.71 | 0.78 | 43 | empty |
| 4 | 597 | 0.70 | 0.79 | 50 | empty |
| 5 | 654 | 0.70 | 0.78 | 52 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1941 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1912 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 753 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 736 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 205 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3JUJ · The crystal structure of apo- UDP-glucose pyrophosphorylase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O25363
- Elsewhere: RCSB PDB 3JUJ · PDBe 3JUJ · UniProt O25363
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