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Crystal structure of the N-terminal domain of the lymphocytic choriomeningitis virus L protein

Analyse Crystal structure of the N-terminal domain of the lymphocytic choriomeningitis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3JSB
Type: protein
Length: 367 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase
EC: 2.7.7.48
UniProt: P14240
Pockets: 4 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 56% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase (EC 2.7.7.48)	protein	173	54% helix, 14% strand	P14240
B	RNA-directed RNA polymerase (EC 2.7.7.48)	protein	194	57% helix, 12% strand	P14240

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	137	0.44	0.76	16	empty
2	50	0.41	0.83	16	empty
3	75	0.33	0.74	18	empty
4	56	0.30	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 724 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3JSB · Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14240
Elsewhere: RCSB PDB 3JSB · PDBe 3JSB · UniProt P14240

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