Research workbench
Crystal structure of bovine procarboxypeptidase a-S6 subunit III, a highly structured truncated zymogen E
Analyse Crystal structure of bovine procarboxypeptidase a-S6 subunit III, a highly… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FON
- Type
- protein
- Length
- 464 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Procarboxypeptidase a-S6
- UniProt
- P05805
- Pockets
- 8 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Procarboxypeptidase a-S6 | protein | 232 | 11% helix, 38% strand | P05805 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.73 | 0.97 | 28 | empty |
| 2 | 157 | 0.57 | 0.82 | 23 | empty |
| 3 | 289 | 0.54 | 0.75 | 41 | empty |
| 4 | 156 | 0.53 | 0.80 | 27 | empty |
| 5 | 51 | 0.52 | 0.88 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1199 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1FON · Crystal structure of bovine procarboxypeptidase a-S6 subunit III, a highly structured… · the same entry in another collection · chain A against A, TM-score 1.00
- P05805 · AlphaFold monomer V2.0 prediction for proproteinase E (P05805) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05805
- Elsewhere: RCSB PDB 1FON · PDBe 1FON · UniProt P05805
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