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Canine parvovirus complexed with Fab E

Analyse Canine parvovirus complexed with Fab E in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3JCX
Type: protein
Length: 770 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Capsid protein 2; Fab E heavy chain; Fab E light chain
UniProt: B2ZG07
Pockets: 15 · best druggability 0.73

Structure

electron microscopy · 3 distinct chains · 2% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Capsid protein 2	protein	548	3% helix, 23% strand	B2ZG07
H	Fab E heavy chain	protein	115	0% helix, 2% strand	—
L	Fab E light chain	protein	107	0% helix, 31% strand	—

Pockets

15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	85	0.73	0.95	29	empty
2	132	0.68	0.89	33	empty
3	561	0.68	0.77	65	empty
4	454	0.62	0.76	41	empty
5	225	0.55	0.78	32	empty

Interfaces

3 interfaces between chains.

H–L · 952 Å² buried · 4 hydrogen bonds · protein-protein
A–H · 468 Å² buried · 4 hydrogen bonds · protein-protein
A–L · 47 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3JCX · Canine Parvovirus complexed with Fab E · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B2ZG07
Elsewhere: RCSB PDB 3JCX · PDBe 3JCX · UniProt B2ZG07

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