Research workbench
Cryo-EM structure of the magnesium channel cora in the closed symmetric magnesium-bound state
Analyse Cryo-EM structure of the magnesium channel cora in the closed symmetric… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3JCF
- Type
- protein
- Length
- 1,745 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Magnesium transport protein cora
- UniProt
- Q9WZ31
- Ligands
- MG
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Magnesium transport protein cora | protein | 349 | 52% helix, 14% strand | Q9WZ31 |
Ligands and binding sites
- MG · Magnesium ion · metal · 13 copies · chains A, E, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 467 | 0.88 | 0.95 | 51 | MG |
| 2 | 234 | 0.84 | 0.96 | 28 | empty |
| 3 | 649 | 0.75 | 0.81 | 55 | empty |
| 4 | 667 | 0.75 | 0.81 | 60 | empty |
| 5 | 668 | 0.75 | 0.81 | 59 | empty |
Interfaces
10 interfaces between chains.
- C–D · 2822 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 2820 Ų buried · 21 hydrogen bonds · protein-protein
- D–E · 2816 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2815 Ų buried · 22 hydrogen bonds · protein-protein
- A–E · 2807 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 3JCF · Cryo-EM structure of the magnesium channel CorA in the closed symmetric magnesium-bound… · the same entry in another collection · chain E against E, TM-score 1.00
- Q9WZ31 · AlphaFold monomer V2.0 prediction for COBALT/MAGNESIUM transport protein cora (Q9WZ31) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZ31
- Elsewhere: RCSB PDB 3JCF · PDBe 3JCF · UniProt Q9WZ31
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