Research workbench
Model of the human EIF3 pci-mpn octamer docked into the 43S-HCV ires EM MAP
Analyse Model of the human EIF3 pci-mpn octamer docked into the 43S-HCV ires EM MAP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3J8B
- Type
- protein
- Length
- 2,542 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit a; Eukaryotic translation initiation…
- EC
- 3.4.19.12
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 8 distinct chains · 66% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 3 subunit a | protein | 488 | 74% helix, 2% strand | — |
| C | Eukaryotic translation initiation factor 3 subunit C | protein | 546 | 68% helix, 2% strand | — |
| E | Eukaryotic translation initiation factor 3 subunit E | protein | 384 | 69% helix, 2% strand | — |
| F | Eukaryotic translation initiation factor 3 subunit F (EC 3.4.19.12) | protein | 232 | 46% helix, 25% strand | — |
| H | Eukaryotic translation initiation factor 3 subunit H | protein | 254 | 53% helix, 19% strand | — |
| K | Eukaryotic translation initiation factor 3 subunit K | protein | 204 | 72% helix, 1% strand | — |
| L | Eukaryotic translation initiation factor 3 subunit L | protein | 258 | 66% helix, 2% strand | — |
| M | Eukaryotic translation initiation factor 3 subunit M | protein | 176 | 72% helix, 5% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1190 | 0.78 | 0.80 | 138 | empty |
| 2 | 1069 | 0.78 | 0.80 | 153 | empty |
| 3 | 840 | 0.77 | 0.81 | 116 | empty |
| 4 | 486 | 0.77 | 0.85 | 98 | empty |
| 5 | 474 | 0.77 | 0.85 | 82 | empty |
Interfaces
15 interfaces between chains.
- F–H · 986 Ų buried · 0 hydrogen bonds · protein-protein
- H–M · 507 Ų buried · 7 hydrogen bonds · protein-protein
- C–E · 467 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 439 Ų buried · 6 hydrogen bonds · protein-protein
- E–L · 393 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3J8B · Model of the human eIF3 PCI-MPN octamer docked into the 43S-HCV IRES EM map · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3J8B · PDBe 3J8B
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