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Structure of MA28-7 neutralizing antibody Fab fragment from electron cryo-microscopy of enterovirus 71 complexed with a Fab fragment

Analyse Structure of MA28-7 neutralizing antibody Fab fragment from electron… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3J3Z
Type: protein
Length: 434 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MA28-7 neutralizing antibody light chain; MA28-7 neutralizing antibody heavy chain
Pockets: 4 · best druggability 0.54

Structure

electron microscopy · 2 distinct chains · 6% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	MA28-7 neutralizing antibody light chain	protein	214	6% helix, 50% strand	—
H	MA28-7 neutralizing antibody heavy chain	protein	220	7% helix, 45% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	341	0.54	0.74	51	empty
2	114	0.43	0.77	20	empty
3	60	0.32	0.76	16	empty
4	84	0.31	0.73	22	empty

Interfaces

1 interface between chains.

L–H · 1882 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3J3Z · Structure of MA28-7 neutralizing antibody Fab fragment from electron cryo-microscopy of… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3J3Z · PDBe 3J3Z

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