Research workbench
Ca model of bovine TRIC/CCT derived from a 4.0 ångström cryo-EM MAP
Analyse Ca model of bovine TRIC/CCT derived from a 4.0 ångström cryo-EM MAP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IYG
- Type
- protein
- Length
- 4,134 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-complex protein 1 subunit theta; T-complex protein 1 subunit gamma; T-complex protein 1…
- UniProt
- Q3ZCI9, Q3T0K2, Q3MHL7, Q2T9X2, Q3ZBH0, Q32L40, Q2NKZ1
- Pockets
- 15 · best druggability 0.45
Structure
electron microscopy · 8 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| Q | T-complex protein 1 subunit theta | protein | 512 | 0% helix, 0% strand | Q3ZCI9 |
| G | T-complex protein 1 subunit gamma | protein | 515 | 0% helix, 0% strand | Q3T0K2 |
| Z | T-complex protein 1 subunit zeta | protein | 517 | 0% helix, 0% strand | Q3MHL7 |
| D | T-complex protein 1 subunit delta | protein | 518 | 0% helix, 0% strand | Q2T9X2 |
| B | T-complex protein 1 subunit beta | protein | 513 | 0% helix, 0% strand | Q3ZBH0 |
| E | T-complex protein 1 subunit | protein | 515 | 0% helix, 0% strand | — |
| A | T-complex protein 1 subunit alpha | protein | 529 | 0% helix, 0% strand | Q32L40 |
| H | T-complex protein 1 subunit eta | protein | 515 | 0% helix, 0% strand | Q2NKZ1 |
Pockets
15 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.45 | 0.73 | 40 | empty |
| 2 | 143 | 0.45 | 0.74 | 29 | empty |
| 3 | 146 | 0.44 | 0.74 | 29 | empty |
| 4 | 150 | 0.43 | 0.73 | 36 | empty |
| 5 | 144 | 0.43 | 0.73 | 36 | empty |
Interfaces
10 interfaces between chains.
- A–H · 652 Ų buried · 0 hydrogen bonds · protein-protein
- D–E · 502 Ų buried · 0 hydrogen bonds · protein-protein
- Q–D · 456 Ų buried · 0 hydrogen bonds · protein-protein
- Z–B · 452 Ų buried · 0 hydrogen bonds · protein-protein
- E–H · 428 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3IYG · Ca model of bovine TRiC/CCT derived from a 4.0 Angstrom cryo-EM map · the same entry in another collection · chain H against H, TM-score 1.00
- Q3ZBH0 · AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit beta (Q3ZBH0) · a predicted model of the same protein · chain B against A, TM-score 0.92
- Q32L40 · AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit alpha (Q32L40) · a predicted model of the same protein · chain A against A, TM-score 0.92
- Q3ZCI9 · AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit theta (Q3ZCI9) · a predicted model of the same protein · chain Q against A, TM-score 0.91
- Q3T0K2 · AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit gamma (Q3T0K2) · a predicted model of the same protein · chain G against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3ZCI9
- Every structure of UniProt Q3T0K2
- Every structure of UniProt Q3MHL7
- Every structure of UniProt Q2T9X2
- Every structure of UniProt Q3ZBH0
- Every structure of UniProt Q32L40
- Every structure of UniProt Q2NKZ1
- Elsewhere: RCSB PDB 3IYG · PDBe 3IYG · UniProt Q3ZCI9 · UniProt Q3T0K2 · UniProt Q3MHL7 · UniProt Q2T9X2 · UniProt Q3ZBH0 · UniProt Q32L40 · UniProt Q2NKZ1
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