Research workbench
Association of the pr peptides with dengue virus blocks membrane fusion at acidic pH
Analyse Association of the pr peptides with dengue virus blocks membrane fusion at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IYA
- Type
- protein
- Length
- 1,421 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelope protein; Prm protein
- UniProt
- P18356
- Pockets
- 2 · best druggability 0.31
Structure
electron microscopy · 3 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Envelope protein | protein | 392 | 0% helix, 0% strand | P18356 |
| D, E, F | Prm protein | protein | 81 | 0% helix, 0% strand | P18356 |
| B, C | Envelope protein | protein | 393 | 0% helix, 0% strand | P18356 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.31 | 0.72 | 18 | empty |
| 2 | 55 | 0.29 | 0.73 | 23 | empty |
Interfaces
6 interfaces between chains.
- B–C · 911 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 330 Ų buried · 0 hydrogen bonds · protein-protein
- C–F · 159 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 158 Ų buried · 0 hydrogen bonds · protein-protein
- B–E · 158 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3IYA · Association of the pr peptides with dengue virus blocks membrane fusion at acidic pH · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18356
- Elsewhere: RCSB PDB 3IYA · PDBe 3IYA · UniProt P18356
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