Research workbench
Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase
Analyse Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IWU
- Type
- protein
- Length
- 912 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-hydroxyisourate hydrolase
- EC
- 3.5.2.17
- UniProt
- Q06S87
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | 5-hydroxyisourate hydrolase (EC 3.5.2.17) | protein | 114 | 9% helix, 43% strand | Q06S87 |
Pockets
6 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 378 | 0.79 | 0.89 | 61 | empty |
| 2 | 940 | 0.76 | 0.79 | 69 | empty |
| 3 | 270 | 0.75 | 0.89 | 39 | empty |
| 4 | 115 | 0.75 | 0.96 | 37 | empty |
| 5 | 251 | 0.74 | 0.88 | 32 | empty |
Interfaces
16 interfaces between chains.
- A–B · 937 Ų buried · 10 hydrogen bonds · protein-protein
- G–H · 931 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 931 Ų buried · 11 hydrogen bonds · protein-protein
- E–F · 930 Ų buried · 10 hydrogen bonds · protein-protein
- B–F · 420 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3IWU · Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase · the same entry in another collection · chain H against H, TM-score 1.00
- Q06S87 · AlphaFold monomer V2.0 prediction for 5-hydroxyisourate hydrolase (Q06S87) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06S87
- Elsewhere: RCSB PDB 3IWU · PDBe 3IWU · UniProt Q06S87
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.