Research workbench
APPEP_WT2 opened state
Analyse APPEP_WT2 opened state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IUJ
- Type
- protein
- Length
- 670 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prolyl endopeptidase
- UniProt
- Q9X6R4
- Pockets
- 7 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prolyl endopeptidase | protein | 670 | 23% helix, 33% strand | Q9X6R4 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 600 | 0.65 | 0.75 | 45 | empty |
| 2 | 230 | 0.48 | 0.74 | 33 | empty |
| 3 | 158 | 0.43 | 0.74 | 28 | empty |
| 4 | 67 | 0.32 | 0.76 | 16 | empty |
| 5 | 57 | 0.31 | 0.76 | 16 | empty |
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 3IUJ · apPEP_WT2 opened state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X6R4
- Elsewhere: RCSB PDB 3IUJ · PDBe 3IUJ · UniProt Q9X6R4
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