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Crystal structure of argp from mycobacterium tuberculosis

Analyse Crystal structure of argp from mycobacterium tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ISP
Type: protein
Length: 553 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hth-type transcriptional regulator RV1985C/MT2039
UniProt: P67665
Pockets: 9 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hth-type transcriptional regulator RV1985C/MT2039	protein	290	41% helix, 20% strand	P67665
B	Hth-type transcriptional regulator RV1985C/MT2039	protein	263	42% helix, 22% strand	P67665

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	215	0.59	0.80	23	empty
2	295	0.54	0.75	35	empty
3	92	0.49	0.81	18	empty
4	143	0.47	0.77	24	empty
5	147	0.45	0.76	27	empty

Interfaces

1 interface between chains.

A–B · 1563 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

3ISP · Crystal structure of ArgP from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P67665
Elsewhere: RCSB PDB 3ISP · PDBe 3ISP · UniProt P67665

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