Research workbench
Crystal structure of mouse ryanodine receptor 2 (residues 1-217)
Analyse Crystal structure of mouse ryanodine receptor 2 (residues 1-217) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IM5
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cardiac CA2+ release channel
- UniProt
- Q9ERN6
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cardiac CA2+ release channel | protein | 173 | 8% helix, 47% strand | Q9ERN6 |
| B | Cardiac CA2+ release channel | protein | 175 | 8% helix, 45% strand | Q9ERN6 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 254 | 0.64 | 0.82 | 29 | empty |
| 2 | 165 | 0.46 | 0.76 | 23 | empty |
| 3 | 112 | 0.42 | 0.77 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 668 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3IM5 · Crystal structure of mouse Ryanodine Receptor 2 (residues 1-217) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ERN6
- Elsewhere: RCSB PDB 3IM5 · PDBe 3IM5 · UniProt Q9ERN6
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