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Structure of E. COLI fabh

Analyse Structure of E. COLI fabh in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3IL9
Type: protein
Length: 634 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3-oxoacyl-[acyl-carrier-protein] synthase 3
EC: 2.3.1.180
UniProt: P0A6R0
Pockets: 8 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180)	protein	317	39% helix, 27% strand	P0A6R0

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	323	0.80	0.91	54	empty
2	187	0.66	0.85	30	empty
3	209	0.65	0.83	36	empty
4	91	0.38	0.76	20	empty
5	72	0.35	0.77	20	empty

Interfaces

1 interface between chains.

A–B · 2297 Å² buried · 44 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

3IL9 · Structure of E. coli FabH · the same entry in another collection · chain A against A, TM-score 1.00
P0A6R0 · AlphaFold monomer V2.0 prediction for 3-oxoacyl-[acyl-carrier- protein] synthase 3… · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A6R0
Elsewhere: RCSB PDB 3IL9 · PDBe 3IL9 · UniProt P0A6R0

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