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Crystal structure of the kelch domain of human KLHL7

Analyse Crystal structure of the kelch domain of human KLHL7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3II7
Type: protein
Length: 288 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kelch-like protein 7
UniProt: Q8IXQ5
Pockets: 2 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kelch-like protein 7	protein	288	0% helix, 52% strand	Q8IXQ5

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 25 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	636	0.78	0.83	47	EDO
2	50	0.25	0.73	17	empty

Compared structures

3II7 · Crystal structure of the kelch domain of human KLHL7 · the same entry in another collection · chain A against A, TM-score 1.00
Q8IXQ5 · AlphaFold monomer V2.0 prediction for kelch-like protein 7 (Q8IXQ5) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IXQ5
Elsewhere: RCSB PDB 3II7 · PDBe 3II7 · UniProt Q8IXQ5

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