Research workbench
Methyltransferase domain of human pr domain-containing protein 10
Analyse Methyltransferase domain of human pr domain-containing protein 10 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IHX
- Type
- protein
- Length
- 495 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pr domain zinc finger protein 10
- UniProt
- Q9NQV6
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pr domain zinc finger protein 10 | protein | 126 | 11% helix, 24% strand | Q9NQV6 |
| B | Pr domain zinc finger protein 10 | protein | 129 | 12% helix, 26% strand | Q9NQV6 |
| C | Pr domain zinc finger protein 10 | protein | 124 | 12% helix, 26% strand | Q9NQV6 |
| D | Pr domain zinc finger protein 10 | protein | 116 | 13% helix, 22% strand | Q9NQV6 |
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 273 | 0.70 | 0.85 | 42 | empty |
| 2 | 284 | 0.69 | 0.84 | 36 | empty |
| 3 | 587 | 0.61 | 0.73 | 54 | empty |
| 4 | 482 | 0.61 | 0.75 | 36 | empty |
| 5 | 350 | 0.54 | 0.74 | 40 | empty |
Interfaces
5 interfaces between chains.
- B–D · 655 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 646 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 254 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 182 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 105 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3IHX · Methyltransferase domain of human PR domain-containing protein 10 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9NQV6 · AlphaFold monomer V2.0 prediction for pr domain zinc finger protein 10 (Q9NQV6) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NQV6
- Elsewhere: RCSB PDB 3IHX · PDBe 3IHX · UniProt Q9NQV6
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