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Crystal structure of reduced C10S spx in complex with the alpha C- terminal domain of RNA polymeras

Analyse Crystal structure of reduced C10S spx in complex with the alpha C- terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3IHQ
Type
protein
Length
182 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Regulatory protein spx; DNA-directed RNA polymerase subunit alpha
EC
2.7.7.6
UniProt
O31602, P20429

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 12% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ARegulatory protein spxprotein11537% helix, 17% strandO31602
BDNA-directed RNA polymerase subunit alpha (EC 2.7.7.6)protein6757% helix, 4% strandP20429

Ligands and binding sites

  • IMD · Imidazole · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

  • A–B · 626 Ų buried · 16 hydrogen bonds · protein-protein

Compared structures

  • 3IHQ · Crystal Structure of Reduced C10S Spx in Complex with the Alpha C-terminal Domain of RNA… · the same entry in another collection · chain A against A, TM-score 1.00
  • O31602 · AlphaFold monomer V2.0 prediction for global transcriptional regulator spx (O31602) · a predicted model of the same protein · chain A against A, TM-score 0.97
  • P20429 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (P20429) · a predicted model of the same protein · chain B against A, TM-score 0.95

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