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Crystal structure of P58(IPK) tpr domain at 2.5 a

Analyse Crystal structure of P58(IPK) tpr domain at 2.5 a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3IEG
Type: protein
Length: 718 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dnaj homolog subfamily C member 3
UniProt: Q91YW3
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Dnaj homolog subfamily C member 3	protein	359	81% helix, 0% strand	Q91YW3

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	395	0.65	0.79	41	empty

Interfaces

1 interface between chains.

A–B · 506 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified, 4 disulfide (engineered, disulfide).

Compared structures

3IEG · Crystal Structure of P58(IPK) TPR Domain at 2.5 A · the same entry in another collection · chain A against A, TM-score 1.00
Q91YW3 · AlphaFold monomer V2.0 prediction for dnaj homolog subfamily C member 3 (Q91YW3) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q91YW3
Elsewhere: RCSB PDB 3IEG · PDBe 3IEG · UniProt Q91YW3

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