Research workbench
Crystal structure of tRNA guanine-N1-methyltransferase from bartonella henselae using mpcs.
Analyse Crystal structure of tRNA guanine-N1-methyltransferase from bartonella henselae… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IEF
- Type
- protein
- Length
- 439 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (guanine-N(1)-)-methyltransferase
- EC
- 2.1.1.31
- UniProt
- Q6G1R9
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.31) | protein | 224 | 42% helix, 20% strand | Q6G1R9 |
| B | TRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.31) | protein | 215 | 42% helix, 20% strand | Q6G1R9 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 537 | 0.74 | 0.82 | 70 | empty |
| 2 | 343 | 0.72 | 0.84 | 58 | empty |
| 3 | 228 | 0.49 | 0.75 | 35 | empty |
| 4 | 53 | 0.25 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 3435 Ų buried · 76 hydrogen bonds · protein-protein
Compared structures
- 3IEF · Crystal structure of tRNA guanine-n1-methyltransferase from Bartonella henselae using… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6G1R9 · AlphaFold monomer V2.0 prediction for tRNA (guanine-N(1)-)-methyltransferase (Q6G1R9) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6G1R9
- Elsewhere: RCSB PDB 3IEF · PDBe 3IEF · UniProt Q6G1R9
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