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The crystal structure of sensory box histidine KINASE/RESPONSE regulator domain from chlorobium tepidum tls

Analyse The crystal structure of sensory box histidine KINASE/RESPONSE regulator domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ICY
Type: protein
Length: 236 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sensor protein
EC: 2.7.13.3
UniProt: Q8KAU2
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sensor protein (EC 2.7.13.3)	protein	118	31% helix, 39% strand	Q8KAU2

Ligands and binding sites

GOL · Glycerol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	255	0.52	0.75	33	empty
2	65	0.30	0.74	13	empty
3	68	0.27	0.72	15	GOL

Interfaces

1 interface between chains.

A–B · 545 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

3ICY · The crystal structure of sensory box histidine kinase/response regulator domain from… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8KAU2
Elsewhere: RCSB PDB 3ICY · PDBe 3ICY · UniProt Q8KAU2

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