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Crystal structure of a beta-lactamase (MB2281C) from mycobacterium bovis, northeast structural genomics consortium target MBR246
Analyse Crystal structure of a beta-lactamase (MB2281C) from mycobacterium bovis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3I7J
- Type
- protein
- Length
- 545 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-lactamase MB2281C
- UniProt
- Q7TYW1
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-lactamase MB2281C | protein | 273 | 36% helix, 19% strand | Q7TYW1 |
| B | Beta-lactamase MB2281C | protein | 272 | 36% helix, 19% strand | Q7TYW1 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 758 | 0.74 | 0.79 | 87 | empty |
Interfaces
1 interface between chains.
- A–B · 582 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 3I7J · Crystal Structure of a beta-lactamase (Mb2281c) from Mycobacterium bovis, Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7TYW1
- Elsewhere: RCSB PDB 3I7J · PDBe 3I7J · UniProt Q7TYW1
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