Research workbench

Antibody structure

Analyse Antibody structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3I75
Type: protein
Length: 435 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody heavy chain; Antibody light chain
Ligands: SO4, CL
Pockets: 5 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Antibody heavy chain	protein	212	6% helix, 52% strand	—
B	Antibody light chain	protein	223	8% helix, 52% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 6 copies · chains A, B
CL · Chloride ion · ion · chains A, B
GOL · Glycerol · additive · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	515	0.60	0.74	57	GOL
2	141	0.44	0.76	23	empty
3	130	0.42	0.75	21	empty
4	84	0.36	0.76	17	CL
5	56	0.30	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 1941 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3I75 · Antibody Structure · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3I75 · PDBe 3I75

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.