Research workbench
Crystal structure of the calponin homology domain of IQGAP1
Analyse Crystal structure of the calponin homology domain of IQGAP1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3I6X
- Type
- protein
- Length
- 656 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS GTPase-activating-like protein IQGAP1
- UniProt
- P46940
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | RAS GTPase-activating-like protein IQGAP1 | protein | 164 | 65% helix, 0% strand | P46940 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 731 | 0.71 | 0.77 | 72 | empty |
| 2 | 637 | 0.68 | 0.77 | 66 | empty |
| 3 | 119 | 0.49 | 0.80 | 24 | empty |
| 4 | 184 | 0.46 | 0.74 | 22 | empty |
| 5 | 158 | 0.46 | 0.76 | 25 | empty |
Interfaces
3 interfaces between chains.
- B–C · 759 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 745 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 200 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3I6X · Crystal structure of the calponin homology domain of IQGAP1 · the same entry in another collection · chain A against A, TM-score 1.00
- P46940 · AlphaFold monomer V2.0 prediction for RAS GTPase-activating-like protein IQGAP1 (P46940) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46940
- Elsewhere: RCSB PDB 3I6X · PDBe 3I6X · UniProt P46940
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