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Tryptophanyl-tRNA synthetase from trypanosoma brucei

Analyse Tryptophanyl-tRNA synthetase from trypanosoma brucei in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3I05
Type: protein
Length: 659 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophanyl-tRNA synthetase
EC: 6.1.1.2
UniProt: Q580R7
Pockets: 6 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tryptophanyl-tRNA synthetase (EC 6.1.1.2)	protein	328	55% helix, 12% strand	Q580R7
B	Tryptophanyl-tRNA synthetase (EC 6.1.1.2)	protein	331	55% helix, 12% strand	Q580R7

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	480	0.68	0.79	39	empty
2	440	0.65	0.78	33	empty
3	163	0.48	0.77	20	empty
4	164	0.47	0.76	19	empty
5	57	0.29	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 1547 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

3I05 · Tryptophanyl-tRNA synthetase from Trypanosoma brucei · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q580R7
Elsewhere: RCSB PDB 3I05 · PDBe 3I05 · UniProt Q580R7

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