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Crystal structure of probable thiosulfate sulfurtransferase CYSA2 (rhodanese-like protein) from mycobacterium tuberculosis

Analyse Crystal structure of probable thiosulfate sulfurtransferase CYSA2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HWI
Type: protein
Length: 538 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thiosulfate sulfurtransferase
EC: 2.8.1.1
UniProt: O05793
Pockets: 2 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thiosulfate sulfurtransferase (EC 2.8.1.1)	protein	267	34% helix, 17% strand	O05793
B	Thiosulfate sulfurtransferase (EC 2.8.1.1)	protein	271	34% helix, 15% strand	O05793

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	350	0.62	0.78	32	empty
2	86	0.42	0.78	18	empty

Interfaces

1 interface between chains.

A–B · 1044 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

3HWI · Crystal structure of probable thiosulfate sulfurtransferase Cysa2 (Rhodanese-like… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O05793
Elsewhere: RCSB PDB 3HWI · PDBe 3HWI · UniProt O05793

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