Research workbench
Crystal structure of the sifa-SKIP(PH) complex
Analyse Crystal structure of the sifa-SKIP(PH) complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HW2
- Type
- protein
- Length
- 413 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein sifa; Pleckstrin homology domain-containing family M member 2
- UniProt
- Q56061, Q8IWE5
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein sifa | protein | 308 | 49% helix, 17% strand | Q56061 |
| B | Pleckstrin homology domain-containing family M member 2 | protein | 105 | 14% helix, 43% strand | Q8IWE5 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 272 | 0.56 | 0.77 | 34 | empty |
| 2 | 139 | 0.39 | 0.73 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 727 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 3HW2 · Crystal structure of the SifA-SKIP(PH) complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q56061 · AlphaFold monomer V2.0 prediction for secreted effector protein sifa (Q56061) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q8IWE5 · AlphaFold monomer V2.0 prediction for pleckstrin homology domain- containing family M… · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q56061
- Every structure of UniProt Q8IWE5
- Elsewhere: RCSB PDB 3HW2 · PDBe 3HW2 · UniProt Q56061 · UniProt Q8IWE5
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