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Crystal structure of a polar amino acid ABC uptake transporter substrate binding protein from streptococcus thermophilus

Analyse Crystal structure of a polar amino acid ABC uptake transporter substrate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HV1
Type: protein
Length: 518 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polar amino acid ABC uptake transporter substrate binding protein
UniProt: Q5M4P7
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polar amino acid ABC uptake transporter substrate binding protein	protein	264	39% helix, 21% strand	Q5M4P7
B	Polar amino acid ABC uptake transporter substrate binding protein	protein	254	40% helix, 22% strand	Q5M4P7

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	856	0.74	0.78	87	empty

Interfaces

1 interface between chains.

A–B · 1072 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified (engineered).

Compared structures

3HV1 · Crystal structure of a polar amino acid ABC uptake transporter substrate binding protein… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5M4P7
Elsewhere: RCSB PDB 3HV1 · PDBe 3HV1 · UniProt Q5M4P7

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