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Solution structure of nucleolin RBD12 in complex with snre RNA

Analyse Solution structure of nucleolin RBD12 in complex with snre RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1FJE
Type: protein + RNA
Length: 197 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Snre RNA; Nucleolin RBD12
UniProt: P08199
Pockets: 2 · best druggability 0.47

Structure

solution nmr · 2 distinct chains · 28% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Snre RNA	rna	22	—	—
B	Nucleolin RBD12	protein	175	28% helix, 30% strand	P08199

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.47	0.79	23	empty
2	77	0.29	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 1183 Å² buried · 27 hydrogen bonds · protein-nucleic

Compared structures

1FJE · Solution structure of nucleolin RBD12 in complex with snre RNA · the same entry in another collection · chain A against A, TM-score 1.00
P08199 · AlphaFold monomer V2.0 prediction for nucleolin (P08199) · a predicted model of the same protein · chain B against A, TM-score 0.50

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08199
Elsewhere: RCSB PDB 1FJE · PDBe 1FJE · UniProt P08199

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